Bipolar patients suffer three times longer from depression than mania


Depression represents the predominant abnormal mood state for treated outpatients with bipolar I and II disorder. Patients have depression three times longer than mania. A large cohort of bipolar 1 and bipolar 2 patients were studied longitudinally. Clinician-adjusted self-ratings of mood were completed daily
for one year for naturalistically treated outpatients with bipolar I (n = 405) or
bipolar II (n = 102) disorder.

The depression/mania ratios were comparable between bipolar I and bipolar II patients in contrast to earlier research.

Limitations
Naturalistic follow-up with all kinds of medication and interventions

Article discussed:
Bipolar Disord. 2007 Aug;9(5):531-5.

Three times more days depressed than manic or hypomanic in both bipolar I and
bipolar II disorder.

Kupka RW, Altshuler LL, Nolen WA, Suppes T, Luckenbaugh DA, Leverich GS, Frye MA,
Keck PE Jr, McElroy SL, Grunze H, Post RM.
doi:10.1111/j.1399-5618.2007.00467.x
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