How does Chocolate protect the Heart?

Dr Shock
June 27, 2008


A number of studies have shown cardiovascular benefits of eating flavanol rich cocoa. In this post I will discuss the possible underlying mechanisms of these cardioprotective properties of chocolate as published in a recent review article: Flavanol-rich cocoa, a cardioprotective nutriceutical.

  • Cocoa flavanols as antioxidants. Antioxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals.Oxidation of low-density lipoprotein (LDL) has been implicated in atherogenesis. Or LDL, a form fat in your blood that plays an important role in harming especially your larger blood vessels can lead to hypertension, lack of oxygen supply to the heart with as complication a hart attack. Antioxidants such as flavanols in chocolate that prevent LDL from oxidizing may reduce atherosclerosis. Although the precise mechanism of flavanol’s antioxidant action has not been agreed upon, research findings do suggest that the consumption of cocoa flavanols in the diet can significantly improve the
    oxidative defense system.
  • Modulation of vascular function. Impaired arterial endothelial function or impaired function of the inner layer of blood vessels has been shown to be a significant early event in atherogenesis and has been associated with an increased cardiovascular risk. Other diseases such as stress, ischemia (short oxygen supply), atherosclerosis, diabetes mellitus, and hypertension, can disrupt endothelial function. As a result, a dysfunctional endothelium may lose its protective effects on the vascular system. The acute consumption of dark chocolate by healthy volunteers have shown the acute dilatation of muscular arteries and an increased arterial elasticity
  • Inhibition of platelets. Platelet aggregation or the forming of small blood cloths is the critical event occurring during the initiation of coronary thrombosis which can lead to cardial infarction. Several studies have provided strong support for the antiaggregatory effects of cocoa flavanols.
  • Antihypertensive effects. The results of 2 separate studies in healthy subjects and later in hypertensives have shown possible benefits of cocoa in blood pressure lowering.This also can be considered as cardioprotective since hypertension leads to an overload of the heart.
  • Anti-infammatory effect. Cocoa flavanols have also been shown to have potential anti-inflammatory activities that are relevant to cardiovascular health. With inflammation, substances are formed which can produce adverse cardiovascular effects.

Now, Dr Shock will never let a change to promote chocolate consumption slip although lack of positive effects are also published on this blog in: Short-term Chocolate Effects on Health.

Moreover, it should also be noted that the evidence for any cardiovascular benefits of cocoa flavanols has been gathered predominantly from short-term and uncontrolled
studies. Therefore, additional research in well-designed, long-term human clinical studies using cocoa would be most helpful in assessing whether flavanol-rich cocoa
could be a potential candidate for the treatment, or possible prevention of cardiovascular disease. The beneficial effects of chocolate also need to be balanced against its high caloric and high fat contents.

ResearchBlogging.org
Mehrinfar, R., Frishman, W.H. (2008). Flavanol-Rich Cocoa. Cardiology in Review, 16(3), 109-115. DOI: 10.1097/CRD.0b013e31815d95e2

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9 Responses to “How does Chocolate protect the Heart?”

  1. I have heard that chocolate has some health benefits. The media portray it as just junk food, which i think is unfair. From reading this i understand alot more about the health benefits that it can have. Dark chocolate is healthier than milk chocolate i believe.

  2. chloe@ petite star on October 3rd, 2008 at 12:15 pm
  3. Yes because dark chocolate contains the most flavanols and tastes better;)

  4. Dr Shock on October 3rd, 2008 at 2:02 pm
  5. [...] You can read about the other possible mechanisms on how polyphenolen can protect the cardiovascular system in a recent post on this blog: How Does Chocolate protect the Heart. [...]

  6. Red Wine and Dark Chocolate for Vascular Health | Dr Shock MD PhD on November 5th, 2008 at 6:25 am
  7. [...] The possible underlying mechanisms of these cardioprotective properties of chocolate can be several. [...]

  8. The Right Chocolate Dose? | Dr Shock MD PhD on January 21st, 2009 at 6:46 am
  9. [...] From the long-term oral administration of cacao liquor polyphenols to rabbits the conclusion was that it had various effects on the cardiovascular and autonomic nervous function in Kurosawa and Kusanagi hypercholesterolaemic rabbits. The cacao liquor polyphenols decreased heart rate and blood pressure and suppressed the impairment of baroreflex function and parasympathetic nervous function without a decrease of serum lipids. These changes were associated with suppression of the development of atherosclerosis. The effect of polyphenolen from cacao could be explained by an effect on cardiovascular and autonomic nervousfunctions. This may result in a decrease in the risk of cardiovascular disease. This adds some new perspectives on the hypothesis about the beneficial effects of chocolate on the heart. [...]

  10. Animal Model for Benefits of Chocolate for Cardiovascular System | Dr Shock MD PhD on March 6th, 2009 at 7:54 am
  11. [...] we discussed the possible ways chocolate protects the cardiovascular system in a post. In short you can see these mechanisms in the picture beneath, from this [...]

  12. Chocolate and Cardiovascular Health | Dr Shock MD PhD on April 28th, 2009 at 8:11 am
  13. [...] The two groups didn’t differ in blood pressures, lipid profile, blood sugar, and measures of oxidative stress either before or after the two weeks of chocolate intake. The authors suggest that flavinoids increase nitric oxyde but based on this research other possible expalnations for it’s working mechanism can not be excluded. For more information about the possible ways chocolate protects the cardiovascular system read: Chocolate and Cardiovascular Health and How does chocolate protect the heart. [...]

  14. Dark Chocolate Improves Coronary Blood Flow | Dr Shock MD PhD on May 21st, 2009 at 8:35 am
  15. [...] flavanol rich cocoa. In a recent post I discussed the possible underlying mechanisms of these cardioprotective properties of chocolate. The mechanism of action of chocolate at the molecular level are poorly understood. In this recent [...]

  16. Chocolate Against Stress | Dr Shock MD PhD on March 16th, 2010 at 8:30 am
  17. [...] flavanol rich cocoa. In a recent post I discussed the possible underlying mechanisms of these cardioprotective properties of chocolate. The mechanism of action of chocolate at the molecular level are poorly understood. In this recent [...]

  18. Science Report | Biology News, Economics News, Computer Science News, Mathematics News, Physics News, Psychology News » Blog Archive » Chocolate Against Stress on March 16th, 2010 at 9:16 am

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