The Neurobiology of Empathy through Pain Research

Dr Shock
February 11, 2009

There are patients with congenital insensitivity to pain (CIP) this is a rare condition. They don’t feel pain, cognition and sensation is otherwise normal; for instance they can still feel discriminative touch (though not always temperature), and there is no detectable physical abnormality. They offer a unique opportunity to test the model of empathy. Does the lack of self-pain representation influence the perception of others’ pain.

CIP patients globally underestimate the pain of others when emotional cues were lacking, and that their pain judgments, in contrast with those of control subjects, are strongly related to interindividual differences in empathy trait. More empathy better pain judgment.

Patients with CIP showed normal fMRI responses to observed pain. The same regions for observed pain in anterior mid-cingulate cortex and anterior insula, were activated. In contrast to healthy controls their empathy trait predicted ventromedial prefrontal responses to somatosensory representations of others’ pain and posterior cingulate responses to emotional representations of others’ pain. CIP patients can acknowledge the pain of others. The amount strongly correlates with their empathic capacity which mainly relies on the engagement of anterior the ventromedial prefrontal cortex (vmPFC) and posterior the ventral posterior cingulate cortex (vPCC) midline structures, which may in part compensate for the patients’ lack of automatic resonance mechanisms.

Why is this study important?
It provides insights into the brain’s ability to evaluate others’ feeling to observed pain without having a specific sensory experience of pain itself. These findings can elucidate the three components of pain processing.

It can be simplistically divided into three domains that are interconnected and/or influence each other through direct or indirect pathways. Most of the regions commonly activated in the CIP-group and C-group are shown in bold in the figure and include regions thought to be involved in emotional processing of pain

Some regions were active in both groups this suggests a generalized or common circuitry for emotional processing. Some regions differ in activation. These differences in activation in regions (medial frontal gyrus and posterior insula and caudate for body parts and the cingulate [mid and posterior]) noted in this study are of greater interest. These four regions are differentially activated in the CIP-group and not in the control group. These regions may provide some interesting insights into the processing of empathy.

  • The medial frontal gyrus is involved in regulation of cognitive control.
  • The mid- and posterior cingulate gyrus is involved in conscious awareness and might also be involved in processing self-relevant emotional and nonemotional information.
  • The posterior insular cortex, sometimes termed the ‘‘sensory insula,’’ may be involved in perception and object recognition
  • pain processing

    How was this study done?

    we used event-related functional magnetic resonance imaging (fMRI) to study the neural correlates of empathy for pain in a group of 13 CIP patients and a control group of 13 healthy subjects. Participants were scanned while observing body parts in painful situations (Experiment 1) or facial expressions of pain (Experiment 2), and were instructed to imagine how the person in the picture feels. We anticipated that CIP patients, deprived as they are of the depicted pain experiences, would show decreased activation in regions supposedly involved in automatic resonance to others’ pain, including the anterior insula (AI) and anterior mid-cingulate cortex (aMCC). In addition, we predicted that the patients’ effort to build a representation of others’ pain might engage brain areas known to be involved in emotional perspective taking, especially midline structures such as medial prefrontal and posterior cingulate cortices

    empathy and pain

    Related post on this blog:
    Patient doctor relationship: Neuroscience of empathy

    ResearchBlogging.org
    N DANZIGER, I FAILLENOT, R PEYRON (2009). Can We Share a Pain We Never Felt? Neural Correlates of Empathy in Patients with Congenital Insensitivity to Pain Neuron, 61 (2), 203-212 DOI: 10.1016/j.neuron.2008.11.023

    D BORSOOK, L BECERRA (2009). Emotional Pain without Sensory Pain—Dream On? Neuron, 61 (2), 153-155 DOI: 10.1016/j.neuron.2009.01.003

     

    6 Responses to “The Neurobiology of Empathy through Pain Research”

    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am
    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am
    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am
    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am
    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am
    1. I consider myself an empathy maven, and this makes so much sense to me. Thanks for the pictures, too. It explains why support groups for patients who have pain are probably more therapeutic than psychotherapy.

    2. therapydoc on February 11th, 2009 at 8:13 pm
    3. [...] Shock MD PhD writes The Neurobiology of Empathy through Pain Research: Some regions were active in both groups this suggests a generalized or common circuitry for [...]

    4. Brain Blogging, Forty-Fifth Edition | Brain Blogger on May 16th, 2009 at 8:27 am
    5. Thanks for submitting this post to our blog carnival. We just published the 45th edition of Brain Blogging and your article was featured!

      Thank you.

      Sincerely,
      Shaheen

    6. Shaheen Lakhan on May 16th, 2009 at 8:35 am
    7. Excellent piece on a subject I frequently discuss during presentations. Suggestion: some excellent further information from VS Ramachandran UCSD at Edge.com – showing the location of the ‘mirror neurons’ which are especially involved with empathy. Your readers will love the study, done during a Super Bowl with fMRI to locate the mirror neurons as a marketing evaluation tool!

      This is an excellent site, well done! Let’s stay connected,
      Chuck

    8. Dr Charles Parker on May 18th, 2009 at 10:55 am
    9. Thanks for the suggestion looks great, let’s stay connected indeed, very honored, kind regards Dr Shock

    10. Dr Shock on May 18th, 2009 at 2:16 pm
    11. [...] More here. [...]

    12. The Neurobiology of Empathy through Pain Research « Empathy for pain on July 20th, 2009 at 12:43 am

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