Deep Brain Stimulation for Treatment Resistant depression

Dr Shock
February 24, 2009

deep brain stimulation

New data are being published about deep brain stimulation and treatment resistant depression. Especially longer follow up is of importance. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, benefits that were largely maintained at 12 months. Moreover, there was no significant loss of effect requiring dose adjustments over time. So once a good stimulus dose, high change that it will remain that way over a long period of time.

With DBS for TRD symptoms typically return rapidly if the device is turned off, if a lead breaks, or if the battery dies. From other areas of neuroscience it is learned that intermittent stimulation of brain areas could provoke longer-term neuroplastic brain changes in these circuits (LTD or LTP), thus moving brain circuits into a more resilient and healthy mode, making symptom recurrence less likely if stimulation is stopped or withdrawn. Exciting trials with intermittent DBS are underway testing these new hypotheses and probably after some time it is probable that the devices can be switched of for good or until recurrence.

In this study twenty patients with TRD underwent serial assessments before and after Subcallosal Cingulate Gyrus DBS. They determined the percentage of patients who achieved a response (50% or greater reduction in the 17-item Hamilton Rating Scale for Depression or remission (scores of 7 or less) after surgery. They also examined changes in brain metabolism associated with DBS, using positron emission tomography.

limbischesysteem

Results from PET scans. The results indicate that SCG DBS produces striking changes in cognitive and limbic brain areas and they provide a biological basis for the observed improvements in depression in these patients. There is a direct activation of the white matter at target that can lead to either metabolic activation or inhibition in distinct remote brain areas. Antidepressant medications, cognitive behavioral therapy, and electroconvulsive therapy produce similar changes in many of these same brain regions.

Adverse Effect

  • Wound Infection and Hardware removal 3 patients
  • Reinsertion of DBS Hardware 1 patient
  • Wound Infection Managed with Antibiotics Alone 1 patient
  • Perioperative Seizure 1 patient
  • Worsening Mood/Irritability 2 patients
  • Perioperative Headache 4 patients
  • Pain at Pulse Generator Site 1 patient
  • No Adverse Effects 7 patients

Limitation of this study is the open label assessment of outcomes

DBS is tried with many more indications. Parkinson’s disease and Obsessive compulsive disorder are the most well known. The Food and Drug Administration has approved deep brain stimulation as a therapy for Obsessive compulsive disorder. In case reports DBS is also tried with addiction, Alzheimers disease, Tourette’s syndrom and even coma. This are all case reports, not evidence based. For a recent overview and intervied about DBS for different indications please read at the Chigaco Tribune, with thanks to @dsaarinen for reminding me on the use of DBS for Alzheimer’s disease.

For a short but very informative video:Deep Brain stimulation for Parkinson’s disease

ResearchBlogging.org
A LOZANO, H MAYBERG, P GIACOBBE, C HAMANI, R CRADDOCK, S KENNEDY (2008). Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression Biological Psychiatry, 64 (6), 461-467 DOI: 10.1016/j.biopsych.2008.05.034

 

5 Responses to “Deep Brain Stimulation for Treatment Resistant depression”

  1. Hi Doc,

    I think this is extremely exciting news for those long suffering patients of MDD (Major Depressive Disorder) refractory to medications and other treatment regimes.

    As a side-note I wanted to point out that based upon CMS (Centers for Medicare & Medicaid Services) here in the U.S. and their decision of May 4, 2007 as it relates to VNS Therapy that “treatment resistant depression” is not recognized by them or contained in the DSM IV whereas chronic and recurrent depression and/or MDD are recognized.

    http://www.vnsdepression.com/pp10-010173-articles_5-4-07-CMS-Kills-Any-Hope-For-VNS.htm

    While Medtronic’s DBS has recently been approved for severe obsessive-compulsive disorder by the FDA the question remains as to whether or not CMS and the health insurance industry in this country will approve reimbursement. Looking further down the road based upon your posting is the similar question of reimbursement of DBS for MDD patients but please rest assured that the sponsors of DBS, in my opinion, have learned from the VNS fiasco and they shall not be using the term “treatment resistant depression.”

    The news you offer is extremely exciting to me as I also cross my fingers for a special friend who is one of participants in the DBS study for MDD.

    Warmly,
    Herb
    VNSdepression.com

  2. herb on February 25th, 2009 at 5:38 pm
  3. Dear Herb,
    Treatment resistant depression is an obscure term, your absolutely right, and I am glad they wont use the term. We in Europe should also loose this term. Thanks for the insight, kind regards Dr shock

  4. Dr Shock on February 25th, 2009 at 7:22 pm
  5. [...] Shock, Deep Brain Stimulation for Treatment Resistant Depression Looks like the benefits are sustained over time in the patients who do [...]

  6. Wednesday Round Up #54 « Neuroanthropology on March 11th, 2009 at 3:39 pm
  7. Unfortunately the DBS video on Parkinson does not work! Any suggestions??

  8. Lutz on March 17th, 2009 at 6:07 pm
  9. [...] stimulation (DBS) may offer hope to patients suffering from chronic and severe depression. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, [...]

  10. New Kind of Brain Stimulation for Treatment Resistant Depression | Dr Shock MD PhD on October 27th, 2009 at 9:12 pm
  1. Hi Doc,

    I think this is extremely exciting news for those long suffering patients of MDD (Major Depressive Disorder) refractory to medications and other treatment regimes.

    As a side-note I wanted to point out that based upon CMS (Centers for Medicare & Medicaid Services) here in the U.S. and their decision of May 4, 2007 as it relates to VNS Therapy that “treatment resistant depression” is not recognized by them or contained in the DSM IV whereas chronic and recurrent depression and/or MDD are recognized.

    http://www.vnsdepression.com/pp10-010173-articles_5-4-07-CMS-Kills-Any-Hope-For-VNS.htm

    While Medtronic’s DBS has recently been approved for severe obsessive-compulsive disorder by the FDA the question remains as to whether or not CMS and the health insurance industry in this country will approve reimbursement. Looking further down the road based upon your posting is the similar question of reimbursement of DBS for MDD patients but please rest assured that the sponsors of DBS, in my opinion, have learned from the VNS fiasco and they shall not be using the term “treatment resistant depression.”

    The news you offer is extremely exciting to me as I also cross my fingers for a special friend who is one of participants in the DBS study for MDD.

    Warmly,
    Herb
    VNSdepression.com

  2. herb on February 25th, 2009 at 5:38 pm
  3. Dear Herb,
    Treatment resistant depression is an obscure term, your absolutely right, and I am glad they wont use the term. We in Europe should also loose this term. Thanks for the insight, kind regards Dr shock

  4. Dr Shock on February 25th, 2009 at 7:22 pm
  5. [...] Shock, Deep Brain Stimulation for Treatment Resistant Depression Looks like the benefits are sustained over time in the patients who do [...]

  6. Wednesday Round Up #54 « Neuroanthropology on March 11th, 2009 at 3:39 pm
  7. Unfortunately the DBS video on Parkinson does not work! Any suggestions??

  8. Lutz on March 17th, 2009 at 6:07 pm
  9. [...] stimulation (DBS) may offer hope to patients suffering from chronic and severe depression. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, [...]

  10. New Kind of Brain Stimulation for Treatment Resistant Depression | Dr Shock MD PhD on October 27th, 2009 at 9:12 pm
  1. Hi Doc,

    I think this is extremely exciting news for those long suffering patients of MDD (Major Depressive Disorder) refractory to medications and other treatment regimes.

    As a side-note I wanted to point out that based upon CMS (Centers for Medicare & Medicaid Services) here in the U.S. and their decision of May 4, 2007 as it relates to VNS Therapy that “treatment resistant depression” is not recognized by them or contained in the DSM IV whereas chronic and recurrent depression and/or MDD are recognized.

    http://www.vnsdepression.com/pp10-010173-articles_5-4-07-CMS-Kills-Any-Hope-For-VNS.htm

    While Medtronic’s DBS has recently been approved for severe obsessive-compulsive disorder by the FDA the question remains as to whether or not CMS and the health insurance industry in this country will approve reimbursement. Looking further down the road based upon your posting is the similar question of reimbursement of DBS for MDD patients but please rest assured that the sponsors of DBS, in my opinion, have learned from the VNS fiasco and they shall not be using the term “treatment resistant depression.”

    The news you offer is extremely exciting to me as I also cross my fingers for a special friend who is one of participants in the DBS study for MDD.

    Warmly,
    Herb
    VNSdepression.com

  2. herb on February 25th, 2009 at 5:38 pm
  3. Dear Herb,
    Treatment resistant depression is an obscure term, your absolutely right, and I am glad they wont use the term. We in Europe should also loose this term. Thanks for the insight, kind regards Dr shock

  4. Dr Shock on February 25th, 2009 at 7:22 pm
  5. [...] Shock, Deep Brain Stimulation for Treatment Resistant Depression Looks like the benefits are sustained over time in the patients who do [...]

  6. Wednesday Round Up #54 « Neuroanthropology on March 11th, 2009 at 3:39 pm
  7. Unfortunately the DBS video on Parkinson does not work! Any suggestions??

  8. Lutz on March 17th, 2009 at 6:07 pm
  9. [...] stimulation (DBS) may offer hope to patients suffering from chronic and severe depression. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, [...]

  10. New Kind of Brain Stimulation for Treatment Resistant Depression | Dr Shock MD PhD on October 27th, 2009 at 9:12 pm
  1. Hi Doc,

    I think this is extremely exciting news for those long suffering patients of MDD (Major Depressive Disorder) refractory to medications and other treatment regimes.

    As a side-note I wanted to point out that based upon CMS (Centers for Medicare & Medicaid Services) here in the U.S. and their decision of May 4, 2007 as it relates to VNS Therapy that “treatment resistant depression” is not recognized by them or contained in the DSM IV whereas chronic and recurrent depression and/or MDD are recognized.

    http://www.vnsdepression.com/pp10-010173-articles_5-4-07-CMS-Kills-Any-Hope-For-VNS.htm

    While Medtronic’s DBS has recently been approved for severe obsessive-compulsive disorder by the FDA the question remains as to whether or not CMS and the health insurance industry in this country will approve reimbursement. Looking further down the road based upon your posting is the similar question of reimbursement of DBS for MDD patients but please rest assured that the sponsors of DBS, in my opinion, have learned from the VNS fiasco and they shall not be using the term “treatment resistant depression.”

    The news you offer is extremely exciting to me as I also cross my fingers for a special friend who is one of participants in the DBS study for MDD.

    Warmly,
    Herb
    VNSdepression.com

  2. herb on February 25th, 2009 at 5:38 pm
  3. Dear Herb,
    Treatment resistant depression is an obscure term, your absolutely right, and I am glad they wont use the term. We in Europe should also loose this term. Thanks for the insight, kind regards Dr shock

  4. Dr Shock on February 25th, 2009 at 7:22 pm
  5. [...] Shock, Deep Brain Stimulation for Treatment Resistant Depression Looks like the benefits are sustained over time in the patients who do [...]

  6. Wednesday Round Up #54 « Neuroanthropology on March 11th, 2009 at 3:39 pm
  7. Unfortunately the DBS video on Parkinson does not work! Any suggestions??

  8. Lutz on March 17th, 2009 at 6:07 pm
  9. [...] stimulation (DBS) may offer hope to patients suffering from chronic and severe depression. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, [...]

  10. New Kind of Brain Stimulation for Treatment Resistant Depression | Dr Shock MD PhD on October 27th, 2009 at 9:12 pm
  1. Hi Doc,

    I think this is extremely exciting news for those long suffering patients of MDD (Major Depressive Disorder) refractory to medications and other treatment regimes.

    As a side-note I wanted to point out that based upon CMS (Centers for Medicare & Medicaid Services) here in the U.S. and their decision of May 4, 2007 as it relates to VNS Therapy that “treatment resistant depression” is not recognized by them or contained in the DSM IV whereas chronic and recurrent depression and/or MDD are recognized.

    http://www.vnsdepression.com/pp10-010173-articles_5-4-07-CMS-Kills-Any-Hope-For-VNS.htm

    While Medtronic’s DBS has recently been approved for severe obsessive-compulsive disorder by the FDA the question remains as to whether or not CMS and the health insurance industry in this country will approve reimbursement. Looking further down the road based upon your posting is the similar question of reimbursement of DBS for MDD patients but please rest assured that the sponsors of DBS, in my opinion, have learned from the VNS fiasco and they shall not be using the term “treatment resistant depression.”

    The news you offer is extremely exciting to me as I also cross my fingers for a special friend who is one of participants in the DBS study for MDD.

    Warmly,
    Herb
    VNSdepression.com

  2. herb on February 25th, 2009 at 5:38 pm
  3. Dear Herb,
    Treatment resistant depression is an obscure term, your absolutely right, and I am glad they wont use the term. We in Europe should also loose this term. Thanks for the insight, kind regards Dr shock

  4. Dr Shock on February 25th, 2009 at 7:22 pm
  5. [...] Shock, Deep Brain Stimulation for Treatment Resistant Depression Looks like the benefits are sustained over time in the patients who do [...]

  6. Wednesday Round Up #54 « Neuroanthropology on March 11th, 2009 at 3:39 pm
  7. Unfortunately the DBS video on Parkinson does not work! Any suggestions??

  8. Lutz on March 17th, 2009 at 6:07 pm
  9. [...] stimulation (DBS) may offer hope to patients suffering from chronic and severe depression. In recent published research about deep brain stimulation for treatment resistant depression, six months after surgery, 60% of patients were responders and 35% met criteria for remission, [...]

  10. New Kind of Brain Stimulation for Treatment Resistant Depression | Dr Shock MD PhD on October 27th, 2009 at 9:12 pm

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