» Posts in the Treatment Resistant Depression Category:

Treatment Resistant Depression and Algorithm Guided Treatment

Dr Shock
July 21, 2009
50 to 60 % of patients with a depressive disorder fail to respond to their first antidepressant. These rates increase in clinical practice setting to 65 to 85%. Estimates of treatment resistant depression (TRD) prevalence varies greatly depending on treatment setting. The lowest TRD prevalence is in primary care and progressively higher rates occur in outpatient psychiatric settings, inpatients settings and academic tertiairy setting. What is Treatment-Resistant Depression? An inadequate response to an adequate course of treatment in a patient meeting criteria for major depressive disorder. Treatment is usually antidepresssants. Depression is not bipolar depression. This diagnoses needs a different approach. An .....read more »

Genes Predict Reponse to Lithium Addition for Treatment Resistant Depression

Dr Shock
May 3, 2008
Genotyping the serotonin transporter gene polymorphism could be a tool for predicting response to a certain treatment pathway. Patients with the s/s genotype who according to the literature seem to be at risk for a less favorable response to antidepressant monotherapy might particularly benefit from augmentation strategies.Thus, early lithium augmentation in these patients (with the s/s genotype) could be a promising strategy and might help to reduce the occurrence of treatment resistance in depressive disorders.There is evidence of interaction between a functional genetic variant in the serotonin transporter gene and life events. Serotonin is an important neurotransmitter believed to play .....read more »