Vagus Nerve Stimulation, Does it Work?

A recent systematic review shows that Vagus Nerve Stimulation (VNS) therapy has been reported to have antidepressant effects in open and longterm studies, but unfortunately the only blinded randomized trial was inconclusive. It is possible that much or all of the improvement reflected a placebo response or spontaneous remission. This makes placing VNS as alternative option for treatment resistant depression hard. Other alternatives are more evidence based: 9 steps for treatment resistant depression. This doesn't exclude vagus nerve stimulation but postpones it to last resort treatment. Particularly for those with a chronic, highly disabling course of their depression. The Pro's for Vagus .....read more »